Transcript Detail IRES Map

Queried Transcript

Transcript Info Conservation Conditional Translation Efficiency
Accession Genome
Location
Trascribed
Gene
5'UTR CDS Stop Codon 3'UTR Average
Phastcon
Score
ER stressed Normal ER/Normal
Ratio
NM_001077441 chr6: -
(location)
BCLAF1 248 bps
(seq)
2241 bps
(seq)
2490 ..2493
(TAA)
4483 bps
(seq)
0.760 0.006 0.000 INF
(q = 0.000E+0*)

Identified Putative IRES Elements

* indicates statistical significance: (Thresholds selected on a ground truth dataset)
1. Conservation Score q-value < 1.000E-6
2. RPI Score q-value < 1.000E-6.
3. Ratio (difference) q-value < 1.000E-6.

IRES Info Conservation Conditional Translation Efficiency
Translation Initiation-related Info Summary for the IRES
Putative IRES Identifying Tools Average
Phastcon Score
(ref)
ER Stressed Normal ER/Normal
Ratio
(ref)
# of eTIS
(ref)
# of nTIS
(ref)
# of uORF
(ref)
# of ITAF
Binding Events
(ref)
RPI
Significance
IRES
activity

(ref)
# of Literature
Evidence
IRES 1
162..248
(seq)
(location)
UTRscan
0.702
(q = 4.959E-3)
0.007 0.000 INF
(q = 3.098E-44*)
2 0 2 2 q = 7.604E-12* -- 0

IRES-Translation Initiation Interaction Map

(TIS refers to the main ORF initiating codon)

Detailed Translation Initiation-Related Data

Phastcon Conservation Scores (Among 19 Mammalian Species)

Interconnected
IRES
Transcript
Location
Chromosomal
Location
Conservation
Score
IRES 1 (162..248) 162 chr6 (-): 136282660 0.870
IRES 1 (162..248) 163 chr6 (-): 136282659 0.874
IRES 1 (162..248) 164 chr6 (-): 136282658 0.884
IRES 1 (162..248) 165 chr6 (-): 136282657 0.883
IRES 1 (162..248) 166 chr6 (-): 136282656 0.900
IRES 1 (162..248) 167 chr6 (-): 136282655 0.904
IRES 1 (162..248) 168 chr6 (-): 136282654 0.909
IRES 1 (162..248) 169 chr6 (-): 136282653 0.917
IRES 1 (162..248) 170 chr6 (-): 136282652 0.916
IRES 1 (162..248) 171 chr6 (-): 136282651 0.944
IRES 1 (162..248) 172 chr6 (-): 136282650 0.952
IRES 1 (162..248) 173 chr6 (-): 136282649 0.953
IRES 1 (162..248) 174 chr6 (-): 136282648 0.946
IRES 1 (162..248) 175 chr6 (-): 136282647 0.952
IRES 1 (162..248) 176 chr6 (-): 136282646 0.951
IRES 1 (162..248) 177 chr6 (-): 136282645 0.943
IRES 1 (162..248) 178 chr6 (-): 136282644 0.937
IRES 1 (162..248) 179 chr6 (-): 136282643 0.923
IRES 1 (162..248) 180 chr6 (-): 136282642 0.879
IRES 1 (162..248) 181 chr6 (-): 136282641 0.841
IRES 1 (162..248) 182 chr6 (-): 136282640 0.753
IRES 1 (162..248) 183 chr6 (-): 136282639 0.733
IRES 1 (162..248) 184 chr6 (-): 136282638 0.668
IRES 1 (162..248) 185 chr6 (-): 136282637 0.654
IRES 1 (162..248) 186 chr6 (-): 136282636 0.670
IRES 1 (162..248) 187 chr6 (-): 136282635 0.690
IRES 1 (162..248) 188 chr6 (-): 136282634 0.691
IRES 1 (162..248) 189 chr6 (-): 136282633 0.696
IRES 1 (162..248) 190 chr6 (-): 136282632 0.702
IRES 1 (162..248) 191 chr6 (-): 136282631 0.712
IRES 1 (162..248) 192 chr6 (-): 136282630 0.707
IRES 1 (162..248) 193 chr6 (-): 136282629 0.707
IRES 1 (162..248) 194 chr6 (-): 136282628 0.689
IRES 1 (162..248) 195 chr6 (-): 136282627 0.721
IRES 1 (162..248) 196 chr6 (-): 136282626 0.728
IRES 1 (162..248) 197 chr6 (-): 136282625 0.721
IRES 1 (162..248) 198 chr6 (-): 136282624 0.718
IRES 1 (162..248) 199 chr6 (-): 136282623 0.736
IRES 1 (162..248) 200 chr6 (-): 136282622 0.737
IRES 1 (162..248) 201 chr6 (-): 136282621 0.766
IRES 1 (162..248) 202 chr6 (-): 136282620 0.836
IRES 1 (162..248) 203 chr6 (-): 136282619 0.889
IRES 1 (162..248) 204 chr6 (-): 136282618 0.906
IRES 1 (162..248) 205 chr6 (-): 136282617 0.928
IRES 1 (162..248) 206 chr6 (-): 136282616 0.957
IRES 1 (162..248) 207 chr6 (-): 136282615 0.966
IRES 1 (162..248) 208 chr6 (-): 136282614 0.968
IRES 1 (162..248) 209 chr6 (-): 136282613 0.971
IRES 1 (162..248) 210 chr6 (-): 136282612 0.976
IRES 1 (162..248) 211 chr6 (-): 136282611 0.976
IRES 1 (162..248) 212 chr6 (-): 136282610 0.971
IRES 1 (162..248) 213 chr6 (-): 136282609 0.960
IRES 1 (162..248) 214 chr6 (-): 136282608 0.935
IRES 1 (162..248) 215 chr6 (-): 136282607 0.875
IRES 1 (162..248) 216 chr6 (-): 136282606 0.730
IRES 1 (162..248) 217 chr6 (-): 136282605 0.704
IRES 1 (162..248) 218 chr6 (-): 136282604 0.627
IRES 1 (162..248) 219 chr6 (-): 136282603 0.395
IRES 1 (162..248) 220 chr6 (-): 136282602 0.216
IRES 1 (162..248) 221 chr6 (-): 136282601 0.208
IRES 1 (162..248) 222 chr6 (-): 136282600 0.204
IRES 1 (162..248) 223 chr6 (-): 136282599 0.178
IRES 1 (162..248) 224 chr6 (-): 136282598 0.157
IRES 1 (162..248) 225 chr6 (-): 136282597 0.141
IRES 1 (162..248) 226 chr6 (-): 136282596 0.129
IRES 1 (162..248) 227 chr6 (-): 136282595 0.095
IRES 1 (162..248) 228 chr6 (-): 136282594 0.070
IRES 1 (162..248) 229 chr6 (-): 136282593 0.050
IRES 1 (162..248) 230 chr6 (-): 136282592 0.049
IRES 1 (162..248) 231 chr6 (-): 136282591 0.037
IRES 1 (162..248) 232 chr6 (-): 136282590 0.036
IRES 1 (162..248) 233 chr6 (-): 136282589 0.041
IRES 1 (162..248) 234 chr6 (-): 136282588 0.131
IRES 1 (162..248) 235 chr6 (-): 136282587 0.240
IRES 1 (162..248) 236 chr6 (-): 136282586 0.371
IRES 1 (162..248) 237 chr6 (-): 136282585 0.522
IRES 1 (162..248) 238 chr6 (-): 136282584 0.573
IRES 1 (162..248) 239 chr6 (-): 136279876 0.915
IRES 1 (162..248) 240 chr6 (-): 136279875 0.902
IRES 1 (162..248) 241 chr6 (-): 136279874 0.913
IRES 1 (162..248) 242 chr6 (-): 136279873 0.932
IRES 1 (162..248) 243 chr6 (-): 136279872 0.956
IRES 1 (162..248) 244 chr6 (-): 136279871 0.964
IRES 1 (162..248) 245 chr6 (-): 136279870 0.975
IRES 1 (162..248) 246 chr6 (-): 136279869 0.989
IRES 1 (162..248) 247 chr6 (-): 136279868 0.996
IRES 1 (162..248) 248 chr6 (-): 136279867 0.998

Potential IRES Structural Form

IRES 1 (162.. 248)

Best Predicted IRES Structural Form:
.........(((((.((......((((((((.(((...((((..((....))..))))))).)))..)))))))..)))))......


Predicted by: SPARSE


Structural RPI Interpretability Significance: q = 7.604E-12*




(Visualization)

Conditional Translation Activity

ER-Stressed Ribisome Profiling (TM-treated)

Interconnected
IRES
Transcript
Location
Chromosomal
Location
Stressed Translation
Activity
IRES 1 (162..248) 162 chr6 (-): 136282660 0.00472548425619
IRES 1 (162..248) 163 chr6 (-): 136282659 0.0048779225165
IRES 1 (162..248) 164 chr6 (-): 136282658 0.0048779225165
IRES 1 (162..248) 165 chr6 (-): 136282657 0.0048779225165
IRES 1 (162..248) 166 chr6 (-): 136282656 0.00533523729744
IRES 1 (162..248) 167 chr6 (-): 136282655 0.00518279903713
IRES 1 (162..248) 168 chr6 (-): 136282654 0.00579253641476
IRES 1 (162..248) 169 chr6 (-): 136282653 0.00609740510358
IRES 1 (162..248) 170 chr6 (-): 136282652 0.00701202683364
IRES 1 (162..248) 171 chr6 (-): 136282651 0.00762177987489
IRES 1 (162..248) 172 chr6 (-): 136282650 0.00853635461412
IRES 1 (162..248) 173 chr6 (-): 136282649 0.00868883986527
IRES 1 (162..248) 174 chr6 (-): 136282648 0.00884124679836
IRES 1 (162..248) 175 chr6 (-): 136282647 0.00899365373145
IRES 1 (162..248) 176 chr6 (-): 136282646 0.00899365373145
IRES 1 (162..248) 177 chr6 (-): 136282645 0.00929854591568
IRES 1 (162..248) 178 chr6 (-): 136282644 0.00929854591568
IRES 1 (162..248) 179 chr6 (-): 136282643 0.00929854591568
IRES 1 (162..248) 180 chr6 (-): 136282642 0.00945095284877
IRES 1 (162..248) 181 chr6 (-): 136282641 0.00960343809992
IRES 1 (162..248) 182 chr6 (-): 136282640 0.0100607372172
IRES 1 (162..248) 183 chr6 (-): 136282639 0.0105180363346
IRES 1 (162..248) 184 chr6 (-): 136282638 0.0105180363346
IRES 1 (162..248) 185 chr6 (-): 136282637 0.00975584503301
IRES 1 (162..248) 186 chr6 (-): 136282636 0.00884124679836
IRES 1 (162..248) 187 chr6 (-): 136282635 0.0080790554968
IRES 1 (162..248) 188 chr6 (-): 136282634 0.00792664856371
IRES 1 (162..248) 189 chr6 (-): 136282633 0.00746934944639
IRES 1 (162..248) 190 chr6 (-): 136282632 0.00746934944639
IRES 1 (162..248) 191 chr6 (-): 136282631 0.0076217877067
IRES 1 (162..248) 192 chr6 (-): 136282630 0.00746934944639
IRES 1 (162..248) 193 chr6 (-): 136282629 0.00746934944639
IRES 1 (162..248) 194 chr6 (-): 136282628 0.00746934944639
IRES 1 (162..248) 195 chr6 (-): 136282627 0.00731691118607
IRES 1 (162..248) 196 chr6 (-): 136282626 0.00716448075757
IRES 1 (162..248) 197 chr6 (-): 136282625 0.00716448075757
IRES 1 (162..248) 198 chr6 (-): 136282624 0.00701204249726
IRES 1 (162..248) 199 chr6 (-): 136282623 0.00670717380844
IRES 1 (162..248) 200 chr6 (-): 136282622 0.00655474337993
IRES 1 (162..248) 201 chr6 (-): 136282621 0.00670718164024
IRES 1 (162..248) 202 chr6 (-): 136282620 0.00670718164024
IRES 1 (162..248) 203 chr6 (-): 136282619 0.006097428599
IRES 1 (162..248) 204 chr6 (-): 136282618 0.00487793818011
IRES 1 (162..248) 205 chr6 (-): 136282617 0.00503036860862
IRES 1 (162..248) 206 chr6 (-): 136282616 0.0047254999198
IRES 1 (162..248) 207 chr6 (-): 136282615 0.00426819297067
IRES 1 (162..248) 208 chr6 (-): 136282614 0.00426819297067
IRES 1 (162..248) 209 chr6 (-): 136282613 0.00442062339918
IRES 1 (162..248) 210 chr6 (-): 136282612 0.004725492088
IRES 1 (162..248) 211 chr6 (-): 136282611 0.00518280686893
IRES 1 (162..248) 212 chr6 (-): 136282610 0.00564010598626
IRES 1 (162..248) 213 chr6 (-): 136282609 0.00548767555775
IRES 1 (162..248) 214 chr6 (-): 136282608 0.00533524512924
IRES 1 (162..248) 215 chr6 (-): 136282607 0.00518279903713
IRES 1 (162..248) 216 chr6 (-): 136282606 0.0048779225165
IRES 1 (162..248) 217 chr6 (-): 136282605 0.00396330861824
IRES 1 (162..248) 218 chr6 (-): 136282604 0.00381087818974
IRES 1 (162..248) 219 chr6 (-): 136282603 0.00381087818974
IRES 1 (162..248) 220 chr6 (-): 136282602 0.00365843992943
IRES 1 (162..248) 221 chr6 (-): 136282601 0.00365843992943
IRES 1 (162..248) 222 chr6 (-): 136282600 0.00365843992943
IRES 1 (162..248) 223 chr6 (-): 136282599 0.00365843992943
IRES 1 (162..248) 224 chr6 (-): 136282598 0.00365843992943
IRES 1 (162..248) 225 chr6 (-): 136282597 0.00396330861824
IRES 1 (162..248) 226 chr6 (-): 136282596 0.00411573904675
IRES 1 (162..248) 227 chr6 (-): 136282595 0.00396331645005
IRES 1 (162..248) 228 chr6 (-): 136282594 0.00426818513887
IRES 1 (162..248) 229 chr6 (-): 136282593 0.00442061556737
IRES 1 (162..248) 230 chr6 (-): 136282592 0.0048779146847
IRES 1 (162..248) 231 chr6 (-): 136282591 0.00503035294501
IRES 1 (162..248) 232 chr6 (-): 136282590 0.00503035294501
IRES 1 (162..248) 233 chr6 (-): 136282589 0.0048779146847
IRES 1 (162..248) 234 chr6 (-): 136282588 0.00487790685289
IRES 1 (162..248) 235 chr6 (-): 136282587 0.00533521380202
IRES 1 (162..248) 236 chr6 (-): 136282586 0.0048779225165
IRES 1 (162..248) 237 chr6 (-): 136282585 0.00853635461412
IRES 1 (162..248) 238 chr6 (-): 136282584 0.00929846759763
IRES 1 (162..248) 239 chr6 (-): 136279876 0.0099082519661
IRES 1 (162..248) 240 chr6 (-): 136279875 0.0099082519661
IRES 1 (162..248) 241 chr6 (-): 136279874 0.0099082519661
IRES 1 (162..248) 242 chr6 (-): 136279873 0.0099082519661
IRES 1 (162..248) 243 chr6 (-): 136279872 0.00945095284877
IRES 1 (162..248) 244 chr6 (-): 136279871 0.0100606588992
IRES 1 (162..248) 245 chr6 (-): 136279870 0.011127742385
IRES 1 (162..248) 246 chr6 (-): 136279869 0.0115850415023
IRES 1 (162..248) 247 chr6 (-): 136279868 0.0114326345692
IRES 1 (162..248) 248 chr6 (-): 136279867 0.0115850415023

Normal Ribisome Profiling (TM-untreaed)

Interconnected
IRES
Transcript
Location
Chromosomal
Location
Normal Translation
Activity
IRES 1 (162..248) 162 chr6 (-): 136282660 0
IRES 1 (162..248) 163 chr6 (-): 136282659 0
IRES 1 (162..248) 164 chr6 (-): 136282658 0
IRES 1 (162..248) 165 chr6 (-): 136282657 0
IRES 1 (162..248) 166 chr6 (-): 136282656 0
IRES 1 (162..248) 167 chr6 (-): 136282655 0
IRES 1 (162..248) 168 chr6 (-): 136282654 0
IRES 1 (162..248) 169 chr6 (-): 136282653 0
IRES 1 (162..248) 170 chr6 (-): 136282652 0
IRES 1 (162..248) 171 chr6 (-): 136282651 0
IRES 1 (162..248) 172 chr6 (-): 136282650 0
IRES 1 (162..248) 173 chr6 (-): 136282649 0
IRES 1 (162..248) 174 chr6 (-): 136282648 0
IRES 1 (162..248) 175 chr6 (-): 136282647 0
IRES 1 (162..248) 176 chr6 (-): 136282646 0
IRES 1 (162..248) 177 chr6 (-): 136282645 0
IRES 1 (162..248) 178 chr6 (-): 136282644 0
IRES 1 (162..248) 179 chr6 (-): 136282643 0
IRES 1 (162..248) 180 chr6 (-): 136282642 0
IRES 1 (162..248) 181 chr6 (-): 136282641 0
IRES 1 (162..248) 182 chr6 (-): 136282640 0
IRES 1 (162..248) 183 chr6 (-): 136282639 0
IRES 1 (162..248) 184 chr6 (-): 136282638 0
IRES 1 (162..248) 185 chr6 (-): 136282637 0
IRES 1 (162..248) 186 chr6 (-): 136282636 0
IRES 1 (162..248) 187 chr6 (-): 136282635 0
IRES 1 (162..248) 188 chr6 (-): 136282634 0
IRES 1 (162..248) 189 chr6 (-): 136282633 0
IRES 1 (162..248) 190 chr6 (-): 136282632 0
IRES 1 (162..248) 191 chr6 (-): 136282631 0
IRES 1 (162..248) 192 chr6 (-): 136282630 0
IRES 1 (162..248) 193 chr6 (-): 136282629 0
IRES 1 (162..248) 194 chr6 (-): 136282628 0
IRES 1 (162..248) 195 chr6 (-): 136282627 0
IRES 1 (162..248) 196 chr6 (-): 136282626 0
IRES 1 (162..248) 197 chr6 (-): 136282625 0
IRES 1 (162..248) 198 chr6 (-): 136282624 0
IRES 1 (162..248) 199 chr6 (-): 136282623 0
IRES 1 (162..248) 200 chr6 (-): 136282622 0
IRES 1 (162..248) 201 chr6 (-): 136282621 0
IRES 1 (162..248) 202 chr6 (-): 136282620 0
IRES 1 (162..248) 203 chr6 (-): 136282619 0
IRES 1 (162..248) 204 chr6 (-): 136282618 0
IRES 1 (162..248) 205 chr6 (-): 136282617 0
IRES 1 (162..248) 206 chr6 (-): 136282616 0
IRES 1 (162..248) 207 chr6 (-): 136282615 0
IRES 1 (162..248) 208 chr6 (-): 136282614 0
IRES 1 (162..248) 209 chr6 (-): 136282613 0
IRES 1 (162..248) 210 chr6 (-): 136282612 0
IRES 1 (162..248) 211 chr6 (-): 136282611 0
IRES 1 (162..248) 212 chr6 (-): 136282610 0
IRES 1 (162..248) 213 chr6 (-): 136282609 0
IRES 1 (162..248) 214 chr6 (-): 136282608 0
IRES 1 (162..248) 215 chr6 (-): 136282607 0
IRES 1 (162..248) 216 chr6 (-): 136282606 0
IRES 1 (162..248) 217 chr6 (-): 136282605 0
IRES 1 (162..248) 218 chr6 (-): 136282604 0
IRES 1 (162..248) 219 chr6 (-): 136282603 0
IRES 1 (162..248) 220 chr6 (-): 136282602 0
IRES 1 (162..248) 221 chr6 (-): 136282601 0
IRES 1 (162..248) 222 chr6 (-): 136282600 0
IRES 1 (162..248) 223 chr6 (-): 136282599 0
IRES 1 (162..248) 224 chr6 (-): 136282598 0
IRES 1 (162..248) 225 chr6 (-): 136282597 0
IRES 1 (162..248) 226 chr6 (-): 136282596 0
IRES 1 (162..248) 227 chr6 (-): 136282595 0
IRES 1 (162..248) 228 chr6 (-): 136282594 0
IRES 1 (162..248) 229 chr6 (-): 136282593 0
IRES 1 (162..248) 230 chr6 (-): 136282592 0
IRES 1 (162..248) 231 chr6 (-): 136282591 0
IRES 1 (162..248) 232 chr6 (-): 136282590 0
IRES 1 (162..248) 233 chr6 (-): 136282589 0
IRES 1 (162..248) 234 chr6 (-): 136282588 0
IRES 1 (162..248) 235 chr6 (-): 136282587 0
IRES 1 (162..248) 236 chr6 (-): 136282586 0
IRES 1 (162..248) 237 chr6 (-): 136282585 0
IRES 1 (162..248) 238 chr6 (-): 136282584 0
IRES 1 (162..248) 239 chr6 (-): 136279876 0
IRES 1 (162..248) 240 chr6 (-): 136279875 0
IRES 1 (162..248) 241 chr6 (-): 136279874 0
IRES 1 (162..248) 242 chr6 (-): 136279873 0
IRES 1 (162..248) 243 chr6 (-): 136279872 0
IRES 1 (162..248) 244 chr6 (-): 136279871 0
IRES 1 (162..248) 245 chr6 (-): 136279870 0
IRES 1 (162..248) 246 chr6 (-): 136279869 0
IRES 1 (162..248) 247 chr6 (-): 136279868 0
IRES 1 (162..248) 248 chr6 (-): 136279867 0

Experimentally-Probed TIS (eTIS)

Interconnected IRES TIS Transcript
Location
TIS Chromosomal
Location
Codon
IRES 1 (162..248) 76..78 chr6 (-) : 136289769 - 136289771.
AUG
IRES 1 (162..248) 249..251 chr6 (-) : 136279864 - 136279866.
AUG

Predicted Non-canonical TIS (nTIS)

Interconnected IRES TIS Transcript
Location
TIS Chromosomal
Location
Non-canonical
Start Codon
Confidence

uORF

Interconnected
IRES
uORF Transcript
Location
uORF Chromosomal
Location
uORF Sequence Sequence
IRES 1 (162..248) 46..105 chr6 (-) : 136289742 - 136289801.
60 bps (seq) AUGGUUUUCCUCGCGUUCUUGAGUCGGGAAAUGGCCGCUGUGUGGUUGCAACGGAGAUAA
IRES 1 (162..248) 76..105 chr6 (-) : 136289742 - 136289771.
30 bps (seq) AUGGCCGCUGUGUGGUUGCAACGGAGAUAA

ITAF Binding Events

Interconnected
IRES
ITAF Type ITAF Transcript
Location
ITAF Chromosomal
Location
ITAF
Sequence
Sequence Identified
Score
IRES 1 (162..248) eIF4A3 (HITS CLIP, Hela cells replicate 1) 135..238 chr6 (-) : 136282584 - 136282687.
104 bps (seq) GAAUUCGAAUUUAGAGUUUAAUUUCUCAGAGCAUUCUCUCCAGGAAGAAUUUUUACAGUAUCUCAAAGACUUCACUUGACUUCUUGAUCCUGCAUAAAACCAAG 14
IRES 1 (162..248) eIF4A3 (HITS CLIP, Hela cells replicate 2) 191..228 chr6 (-) : 136282594 - 136282631.
38 bps (seq) AGUAUCUCAAAGACUUCACUUGACUUCUUGAUCCUGCA 3

IRES Activity Measurements

Interconnected
IRES
IRES
Activity
Promoter
Activity
Splicing
Activity
Matched
Transcript
Location
Matched Transcript Sequence Matched Chromosomal
Location
Designed
Human Oligo
Sequence
Designed Oligo Sequence BLASTN
Query Cover
BLASTN
Percent Identity

IRES Elements Verified in the Literature

Interconnected
IRES
Matched
Transcript
Location
Matched Transcript Sequence Matched Chromosomal
Location
Literature
Verified Sequence
Verified Sequence BLASTN
Query Cover
BLASTN
Percent Identity
Reference

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